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LANDMARK TRIALS
- Know the studies that changed when—and where—we operate
- THE EVIDENCE TIMELINE
- 2006 — GPi dystonia — Sham-controlled: significant motor improvement
- 2008–10 — CSP 468 / COMPARE — STN vs GPi: target-specific trade-offs
- 2013 — EARLYSTIM — Earlier STN DBS improved QoL vs medical therapy
- 2016 — NSTAPS 3-y — STN: greater off-motor improvement; more medication reduction
- 2019 — VIM long-term — Benefit persists, but habituation / disease progression matter
- 2024 — VIM vs PSA RCT — Comparable tremor reduction; PSA lower intensity + selected advantages
- Teaching point: trials define probabilities and trade-offs; they do not replace phenotype-based target selection.
- Dr Vikas Kathuria | MCh Neurosurgery
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47A LANDMARK DBS TRIAL TIMELINE — INSERT AUTHENTIC IMAGE
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AssociationModule 10 · Slide 47