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HOW DBS WORKS
- ELECTRIC FIELD — Generated around the contact
- NEURAL ELEMENTS RECRUITED — Cell bodies, axons, fibres, terminals
- LOCAL & AXONAL EFFECTS — Modulation of neural activity
- CIRCUIT / NETWORK MODULATION — Alteration of pathological activity
- CLINICAL EFFECT — Improvement in symptoms
- DBS ≠ simply “ON” or “OFF”
- Possible mechanisms include: action-potential modulation, axonal activation, synaptic effects, oscillatory modulation, network-level effects, neurochemical effects. The precise therapeutic mechanism remains incompletely resolved.
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ELECTRIC FIELD
Real clinical image required
Image typeSchematic / diagram
DescriptionDBS lead with an expanding stimulation field, overlaid with the sequence CONTACT → ELECTRIC FIELD → NEURAL ELEMENTS → NETWORK → CLINICAL EFFECT.
Clinical purposeShow that the contact is the source, not the boundary, of the therapeutic effect.
Suggested sourceConceptual diagram, or a modelling figure from a peer-reviewed publication.
Copyright statusNot yet cleared
CaptionTo be written with the final image
AssociationModule 01 · Slide 02
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BASAL GANGLIA NETWORK
Real clinical image required
Image typeSchematic / diagram
DescriptionProperly sourced anatomical/network diagram showing cortex, striatum, GPe, GPi, STN, SNr and thalamus, clearly distinguishing motor circuitry from the entire basal-ganglia system.
Clinical purposeProvide the circuit substrate for every later discussion of target choice and stimulation effect.
Suggested sourceAtlas or peer-reviewed publication figure; licence to be confirmed.
Copyright statusTo be confirmed before publication.
CaptionTo be written with the final image
AssociationModule 01 · Slide 02